Spark Riders 3000

Play as the crew of the Spark, the spaceship equipped with the most advanced AI in the universe. Your mission is to deliver precious cargo to the four corners of the galaxy to ensure the survival of humanity. Beware, alien pirates and hostile environments await you, so only the best will arrive in one piece.

Spark Riders 3000 is a hybrid single player/co-operative tower defense and survival game for 1 to 4 players in which players must coordinate their actions to ensure the success of their mission.
Each scenario is different and you will have to adapt quickly to avoid seeing your ship destroyed and its cargo intercepted by alien pirates.
The goal is simple: reach your delivery point without having one of the ship's vital rooms destroyed.

—description from the publisher